Interchromosomal Homology Searches Drive Directional ALT Telomere Movement and Synapsis
نویسندگان
چکیده
منابع مشابه
Interchromosomal Homology Searches Drive Directional ALT Telomere Movement and Synapsis
Telomere length maintenance is a requisite feature of cellular immortalization and a hallmark of human cancer. While most human cancers express telomerase activity, ∼10%-15% employ a recombination-dependent telomere maintenance pathway known as alternative lengthening of telomeres (ALT) that is characterized by multitelomere clusters and associated promyelocytic leukemia protein bodies. Here, w...
متن کاملPubServer: literature searches by homology
PubServer, available at http://pubserver.burnham.org/, is a tool to automatically collect, filter and analyze publications associated with groups of homologous proteins. Protein entries in databases such as Entrez Protein database at NCBI contain information about publications associated with a given protein. The scope of these publications varies a lot: they include studies focused on biochemi...
متن کاملALT Telomeres Borrow from Meiosis to Get Moving
Telomere clustering is required for the homologous recombination events that maintain chromosome ends in cells relying on alternative lengthening of telomeres (ALT). New data demonstrate that damage signaling at telomeres, a likely step in activating maintenance mechanisms, induces directional movement and synapsis driven by the machinery responsible for recombination in meiosis.
متن کاملFalse Discovery Rate for Homology Searches
While many different aspects of retrieval algorithms (e.g., BLAST) have been studied in depth, the method for determining the retrieval threshold has not enjoyed the same attention. Furthermore, with genetic databases growing rapidly, the challenges of multiple testing are escalating. In order to improve search sensitivity, we propose the use of the false discovery rate (FDR) as the method to c...
متن کاملFaster sequence homology searches by clustering subsequences
MOTIVATION Sequence homology searches are used in various fields. New sequencing technologies produce huge amounts of sequence data, which continuously increase the size of sequence databases. As a result, homology searches require large amounts of computational time, especially for metagenomic analysis. RESULTS We developed a fast homology search method based on database subsequence clusteri...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell
سال: 2014
ISSN: 0092-8674
DOI: 10.1016/j.cell.2014.08.030